David King-Stephens, M.D. , Scientist; Director of Neurophysiology at CPMC, Co-Director of the Sutter Pacific Epilepsy Program

California Pacific CURRENTS: The online journal of CPMC Research Institute

Clinical research to improve the treatment of seizure disorders
  • Lateralization of temporal lobe epilepsy with long-term ambulatory intracranial monitoring

    Results of long-term ambulatory electrocorticography from 82 subjects with localization related epilepsy of temporal lobe onset who were studied with bilateral hippocampal depth leads or subtemporal cortical strip leads while participating in the pivotal trial of the RNS® System cranially implanted responsive neurostimulator were presented at the American Society of Epilepsy 2013 Annual Meeting.

    The figure above describes the intervals of time before bilateral onsets were observed in the 70 subjects with bilateral onsets recorded by the neurostimulator. The average time to record bilateral seizure onsets after the neurostimulator implant was 41.3 days (median: 13.5 days, range: 0 – 376 days). 30.5% (25/70) of the subjects had bilateral onsets observed during the first week of recording post-implant, 14.6% (12/70) during the second week, 6.1% (5/70) during the third week and 34.1% (28/70) had bilateral onsets observed over 21 days post neurostimulator implant.

    Source:  King-Stephens D, Weber P, Laxer D, Mirro E, Morrell M, et al. Lateralization of temporal lobe epilepsy with long-term ambulatory intracranial monitoring using the RNS® System: Experience in 82 patients. (Figure 3) A.02. American Society of Epilepsy 2013 Annual Meeting. Washington, D.C.

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Research Overview

  • Dr. King-Stephens specializes in neurological treatments for uncontrolled epilepsy and other seizure disorders.
  • He helps lead clinical trials of new therapies for epilepsy, and investigates  neuromodulation, surgical treatment of seizure disorders, invasive electroencephalogram (EEG) techniques, and intraoperative EEG mapping.
  • Dr. King-Stephens’ research has been published in Neurology, Molecular Medicine, and the Journal of Nuclear Medicine. He has authored numerous editorials, reviews, and book chapters on the anatomy, physiology, management, and treatment of epilepsy.

Training
 

Dr. King-Stephens obtained his M.D. at the Escuela Mexicana de Medicina, Universidad La Salle in Mexico City. He completed a residency in neurology at Columbia-Presbyterian Medical Center, and a fellowship in epilepsy and EEG at Yale University in New Haven, Connecticut.


Publication Search

Publications

Geller EB, Skarpaas TL, Gross RE, Goodman RR, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Cash SS, Cole AJ, Duckrow RB, Edwards JC, Eisenschenk S, Fessler J, Fountain NB, Goldman AM, Gwinn RP, Heck C, Herekar A, Hirsch LJ, Jobst BC, King-Stephens D, Labar DR, Leiphart JW, Marsh WR, Meador KJ, Mizrahi EM, Murro AM, Nair DR, Noe KH, Park YD, Rutecki PA, Salanova V, Sheth RD, Shields DC, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness PC, Vossler DG, Wharen RE Jr, Worrell GA, Yoshor D, Zimmerman RS, Cicora K, Sun FT, Morrell MJ, Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy. Epilepsia

Jobst BC, Kapur R, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Boggs JG, Cash SS, Cole AJ, Duchowny MS, Duckrow RB, Edwards JC, Eisenschenk S, Fessler AJ, Fountain NB, Geller EB, Goldman AM, Goodman RR, Gross RE, Gwinn RP, Heck C, Herekar AA, Hirsch LJ, King-Stephens D, Labar DR, Marsh WR, Meador KJ, Miller I, Mizrahi EM, Murro AM, Nair DR, Noe KH, Olejniczak PW, Park YD, Rutecki P, Salanova V, Sheth RD, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness P, Vossler DG, Wharen RE Jr, Worrell GA, Yoshor D, Zimmerman RS, Skarpaas TL, Morrell MJ, Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia

Foo F, King-Stephens D, Weber P, Laxer K, Parvizi J, Knight RT, Differential Processing of Consonance and Dissonance within the Human Superior Temporal Gyrus. Front Hum Neurosci

King-Stephens D, Mirro E, Weber PB, Laxer KD, Van Ness PC, Salanova V, Spencer DC, Heck CN, Goldman A, Jobst B, Shields DC, Bergey GK, Eisenschenk S, Worrell GA, Rossi MA, Gross RE, Cole AJ, Sperling MR, Nair DR, Gwinn RP, Park YD, Rutecki PA, Fountain NB, Wharen RE, Hirsch LJ, Miller IO, Barkley GL, Edwards JC, Geller EB, Berg MJ, Sadler TL, Sun FT, Morrell MJ, Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography. Epilepsia

Bergey GK, Morrell MJ, Mizrahi EM, Goldman A, King-Stephens D, Nair D, Srinivasan S, Jobst B, Gross RE, Shields DC, Barkley G, Salanova V, Olejniczak P, Cole A, Cash SS, Noe K, Wharen R, Worrell G, Murro AM, Edwards J, Duchowny M, Spencer D, Smith M, Geller E, Gwinn R, Skidmore C, Eisenschenk S, Berg M, Heck C, Van Ness P, Fountain N, Rutecki P, Massey A, O'Donovan C, Labar D, Duckrow RB, Hirsch LJ, Courtney T, Sun FT, Seale CG, Long-term treatment with responsive brain stimulation in adults with refractory partial seizures. Neurology

Heck CN, King-Stephens D, Massey AD, Nair DR, Jobst BC, Barkley GL, Salanova V, Cole AJ, Smith MC, Gwinn RP, Skidmore C, Van Ness PC, Bergey GK, Park YD, Miller I, Geller E, Rutecki PA, Zimmerman R, Spencer DC, Goldman A, Edwards JC, Leiphart JW, Wharen RE, Fessler J, Fountain NB, Worrell GA, Gross RE, Eisenschenk S, Duckrow RB, Hirsch LJ, Bazil C, O'Donovan CA, Sun FT, Courtney TA, Seale CG, Morrell MJ, Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial. Epilepsia

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David King-Stephens, M.D. , Scientist; Director of Neurophysiology at CPMC, Co-Director of the Sutter Pacific Epilepsy Program
Primary Research Interests
  • Management of epilepsy and seizure disorders

Epilepsy Clinical Trials