Ryan H. Dougherty, M.D. , Scientist; Director of the Adult Cystic Fibrosis Care Center at CPMC

California Pacific CURRENTS: The online journal of CPMC Research Institute

Leadership in pulmonary and critical care medicine; improved treatments for asthma, COPD and cystic fibrosis
  • Immunohistochemistry specimens for mast cells and basophils

    Immunohistochemistry in endobronchial biopsy specimens for mast cells and basophils. A and B, Serial sections show tryptase-positive cells within the epithelium (arrows; A) and absence of basophils (B). C and D, Serial sections show tryptase-positive cells within the epithelium (arrow; C) and chymase-positive cells in the submucosa (arrow; D). E, Anti-CPA3 shows CPA3-positive cells (arrows).

    Source: Dougherty RH, Sidhu SS, Raman K, et al. Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma.  J Allergy Clin Immunol 2010;125(5):1046-1053.e8. doi: 10.1016/j.jaci.2010.03.003. (Figure 5)

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Research Overview

  • Dr. Dougherty pursues clinical-translational research in pulmonary/airway diseases including asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. He is board certified in critical care medicine and internal medicine.
  • He has extensive experience studying the viscoelastic properties of sputum during acute asthma exacerbation and cystic fibrosis.
  • As Director of the Adult Cystic Fibrosis Care Center at CPMC, Dr. Dougherty collaborates with other specialists to provide comprehensive care for patients with cystic fibrosis. His research in this area includes therapeutic drug trials, a collaboration with the Centers for Disease Control and Prevention on quality control of cystic fibrosis mutation genotyping, and quality improvement projects for the illness.
  • Dr. Dougherty is conducting a retrospective study using national cystic fibrosis registry data to assess the role of airways infection in cystic fibrosis patient outcomes.

Training


Dr. Dougherty obtained his M.D. from Johns Hopkins School of Medicine in Baltimore, Maryland. He completed residency training in internal medicine at Massachusetts General Hospital in Boston, and a pulmonary/critical care fellowship at the University of California, San Francisco.


 

Publication Search

Publications

Kerr SC, Carrington SD, Oscarson S, Gallagher ME, Solon M, Yuan S, Ahn JN, Dougherty RH, Finkbeiner WE, Peters MC, Fahy JV, Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma. Am J Respir Crit Care Med

Innes AL, McGrath KW, Dougherty RH, McCulloch CE, Woodruff PG, Seibold MA, Okamoto KS, Ingmundson KJ, Solon MC, Carrington SD, Fahy JV, The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbation. Am J Respir Crit Care Med

Dougherty RH, Sidhu SS, Raman K, Solon M, Solberg OD, Caughey GH, Woodruff PG, Fahy JV, Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma. J Allergy Clin Immunol

Innes AL, Carrington SD, Thornton DJ, Kirkham S, Rousseau K, Dougherty RH, Raymond WW, Caughey GH, Muller SJ, Fahy JV, Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma. Am J Respir Crit Care Med

Potapova O, Anisimov SV, Gorospe M, Dougherty RH, Gaarde WA, Boheler KR, Holbrook NJ, Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression. Cancer Res

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Ryan H. Dougherty, M.D. , Scientist; Director of the Adult Cystic Fibrosis Care Center at CPMC
Primary Research Interests
  • Airway/pulmonary diseases including asthma, COPD and cystic fibrosis
  • Fibrosing colonopathy