Susan Woolley-Levine, Ph.D. , Scientist; Clinical Neuropsychologist at CPMC

California Pacific CURRENTS: The online journal of CPMC Research Institute

Cognitive and behavioral screening of amyotrophic lateral sclerosis
  • Neuroanatomical Correlates of Apathy in ALS Using 4 Tesla Diffusion Tensor MRI

    FA maps of ALS subjects and controls. The display of regions on the statistical maps was based on an uncorrected threshold at p = 0.005. Color scale bars, expressed as T-values for each test, range from the significance thresholds to the greatest level of change. Positive T-values indicate a positive association (e.g. , decreased FA associated with increased clinical scores), and negative T-values  indicate the negative association. A. Maps of regions with strong fractional anisotropy (FA) reductions in ALS (n = 24) relative to controls (n = 24). B. Maps of regions with FA reductions that associated with decreased ALSFRS-R scores in ALS patients (n = 24). C. Maps of regions with reduced FA associated with greater increases in apathy scores (negative association) in ALS patients. D. Maps of regions with reduced FA associated with greater current apathy scores in ALS patients. E. An overlap of the maps from the four tests above.

    Source: Woolley, SC, Zhang, Y, Schuff, N, Weiner, MW, Katz, JS.  Neuroanatomical Correlates of Apathy in ALS Using 4 Tesla Diffusion Tensor MRI.  Amyotrophic Lateral Sclerosis 2011;12:52-58, copyright © 2011, Informa Healthcare. Reproduced with permission of Informa Healthcare.

     

+

Research Overview

  • A clinical neuropsychologist, Dr. Woolley-Levine’s primary research focus is the cognitive and behavioral screening of amyotrophic lateral sclerosis (ALS) patients.
  • She developed the only empirically validated cognitive screen for ALS (ALS CBS™), used to detect frontotemporal dementia.
  • Dr. Woolley-Levine co-authored the practice parameters for the treatment of ALS, and the consensus criteria for the diagnosis of frontotemporal cognitive and behavioral syndromes in ALS.
  • She has collaborated with the SFVA in neuroimaging studies, and has consulted on other studies in hepatic encephalopathy and Alzheimer’s disease.

Training

Dr. Woolley-Levine obtained her Ph.D. in clinical psychology from the California School of Professional Psychology in Alameda, California.  Predoctoral and postdoctoral training was completed at CPMC.


 

Publication Search

Publications

Strong MJ, Abrahams S, Goldstein LH, Woolley S, Mclaughlin P, Snowden J, Mioshi E, Roberts-South A, Benatar M, HortobáGyi T, Rosenfeld J, Silani V, Ince PG, Turner MR, Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria. Amyotroph Lateral Scler Frontotemporal Degener

Branco LM, Zanao T, De Rezende TJ, Casseb RF, Balthazar MF, Woolley SC, França MC Jr, Transcultural validation of the ALS-CBS Cognitive Section for the Brazilian population. Amyotroph Lateral Scler Frontotemporal Degener

Tremolizzo L, Pellegrini A, Susani E, Lunetta C, Woolley SC, Ferrarese C, Appollonio I, Behavioural But Not Cognitive Impairment Is a Determinant of Caregiver Burden in Amyotrophic Lateral Sclerosis. Eur Neurol

Murphy J, Factor-Litvak P, Goetz R, Lomen-Hoerth C, Nagy PL, Hupf J, Singleton J, Woolley S, Andrews H, Heitzman D, Bedlack RS, Katz JS, Barohn RJ, Sorenson EJ, Oskarsson B, Fernandes Filho JA, Kasarskis EJ, Mozaffar T, Rollins YD, Nations SP, Swenson AJ, Koczon-Jaremko BA, Mitsumoto H, ALS COSMOS., Cognitive-behavioral screening reveals prevalent impairment in a large multicenter ALS cohort. Neurology

Nidos A, Kasselimis DS, Simos PG, Rentzos M, Alexakis T, Zalonis I, Zouvelou V, Potagas C, Evdokimidis I, Woolley SC, Frontotemporal Dysfunction in Amyotrophic Lateral Sclerosis: A Discriminant Function Analysis. Neurodegener Dis

VIEW ALL
Susan Woolley-Levine, Ph.D. , Scientist; Clinical Neuropsychologist at CPMC
Primary Research Interests
  • Cognitive and behavioral screening of ALS patients
  • Neuroimaging

Research News & Highlights

Research by Dr. Woolley and colleauges led to revised diagnostic criteria for amyotrophic lateral sclerosis frontotemporal spectrum disorder (ALS-FTSD). Click here to receive one of 50 FREE downloads of the full paper.