William Goodson, M.D. , Scientist; Surgeon at CPMC

California Pacific CURRENTS: The online journal of CPMC Research Institute

Diagnosis and care of breast diseases
  • DNA damage incurred by TPA exposure

    Terephthalic acid (TPA) exposure promotes hallmarks of malignancy in benign high-risk donor breast epithelial cells, which include receptor activation, apoptosis evasion, cell cycle disruption, and persistent DNA damage. The dual potential of TPA to cause direct cellular damage, and to induce apoptosis evasion could enable persistence of potential cancerous precursors for future progression.

    DNA damage incurred by TPA exposure overrides the S-phase increase expected of an ERα-activating XE. Thus, lack of increased cell proliferation is insufficient as an endpoint for determining chemical safety in in vitro tests.

    Source: Low-dose exposure of non-malignant breast epithelial cells to the polyester and PET precursor, terephthalic acid, triggers broad-based dysfunctional changes. Luciani-Torres MG,  Goodson III, WH, Dairkee SH. San Antonio Breast Cancer Symposium 2013. Abstract #110.

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Research Overview

  • Dr. Goodson studies interactions between environmental chemicals and the development of cancer; techniques to improve breast examinations and lumpectomies; quality assurance for timely diagnosis of breast cancer; and growth rates of the disease. Some of his research in this area involves collaborations with Dr. Shanaz Dairkee.
  • He was the only surgeon in Northern California to participate in the original clinical trials demonstrating that lumpectomy is a safe and effective treatment for early breast cancer.
  • Dr. Goodson has published numerous peer-reviewed articles on most aspects of breast diseases, wound healing, and patient care ethics.

Training

Dr. Goodson obtained his M.D. from Harvard Medical School in Boston, Massachusetts. He completed residency training at University Hospitals of Cleveland and a fellowship at Boston’s Children’s Hospital.


 

Publication Search

Publications

Miller MF, Goodson WH, Manjili MH, Kleinstreuer N, Bisson WH, Lowe L, Low-Dose Mixture Hypothesis of Carcinogenesis Workshop: Scientific Underpinnings and Research Recommendations. Environ Health Perspect

Goodson WH 3rd, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondráček J, Raju J, Roman J, Wise JP Sr, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engström W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z, Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis

Goodson WH 3rd, Understanding sexual violence perpetration. JAMA Pediatr

Goodson WH 3rd, Luciani MG, Sayeed SA, Jaffee IM, Moore DH 2nd, Dairkee SH, Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women. Carcinogenesis

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William Goodson, M.D. , Scientist; Surgeon at CPMC
Primary Research Interests
  • Effects of xenoestrogens and cancer risk
  • Early diagnosis and treatment of breast cancer