Dairkee Lab

California Pacific CURRENTS: The online journal of CPMC Research Institute

Non-malignant breast epithelial cells and response to natural estrogen (estradiol) and ubiquitous environmental estrogenic mimics
A collage representing human non-malignant breast epithelial cells grown in culture to measure personalized response to natural estrogen (estradiol) and environmental estrogenic mimics such as bisphenol-A (BPA).
Overview

Since breast cancer is a complex malignancy with multiple disease mechanisms, the use of well-designed cellular models can provide much-needed insights into understanding its origins as an approach to prevention and improved treatment.

Foundational research from our lab led to the development of novel tumor cell models from clinical samples. We are applying these tools to understand early molecular and genetic changes underlying the progression of breast cancer, and to investigate genetic signatures’ associated with cancer aggressiveness. Truly innovative strategies for drug discovery and testing are rare. We are devising techniques—guided by the molecular characteristics of a wide clinical spectrum of cultured cancer cells—to predict and improve response to breast cancer therapy.

Using our novel non-malignant breast cell models, our lab is studying how environmental chemicals that mimic the effects of estrogen (such as bisphenol-A and PET) may contribute to the development and progression of cancer in some individuals.

Lead Investigator
Current Projects
  • CPMCRI's Cancer Avatar Project
  • Creating patient-derived cellular models for cancer drug development and testing
  • Investigating pathway perturbations induced by environmental estrogens in breast cells from human donors
  • Evaluating the impact of mixtures of high-volume consumption chemicals on normal cell regulation