Gregory Tranah, Ph.D., Senior Scientist

California Pacific CURRENTS: The online journal of CPMC Research Institute

Exploring the genetic basis of aging and age-related illnesses
  • Circadian gene variation

    The figure in the upper left shows a highly conserved set of clock genes regulating the timing of the central pacemaker in the SCN through a transcription-translation feedback loop. The bottom left section shows a regional association plot of the NPAS2 gene region. Gray circles mark single nucleotide polymorphisms (SNP) association P > 0.05, blue circles mark The Osteoporotic Fractures in Men (MrOS) sleep onset time SNP association P ≤ 0.05, and red circles mark The Study of Osteoporotic Fractures (SOF) pseudo-F statistic SNP association P ≤ 0.05. The graph in the upper right shows the interaction between core circadian genes on sleep onset time.

    Source: Evans DS et al. and Tranah GJ on behalf of the Osteoporotic Fractures in Men (MrOS) Study Group. Common genetic variants in ARNTL and NPAS2 and at chromosome 12p13 are associated with objectively measured sleep traits in the elderly. Sleep 2013 Mar 1;36(3):431-46. (Adapted from Figures 2 and 3)

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Research Overview

  • Research in the Tranah lab focuses on the epidemiology of aging and age-related diseases.
  • In collaboration with scientists from the Study of Osteoporotic Fractures (SOF) in women, the Study of Osteoporosis in Men (MrOS), and the Health, Aging and Body Composition Study, he investigates the genetics of cognitive function, osteoporosis, osteoarthritis, sleep, and the role of mitochondrial DNA in human energetics and aging.
  • Dr. Tranah is leading a deep sequencing study to identify genes associated with centenarians, and is exploring gene-environment interactions using genome-wide association studies.
  • He oversees gene sequencing, epidemiology, and data analysis for CPMCRI's Cancer Avatar Project.

Learn more about research in the Center for Research on Human Aging.

A new documentary features Dr. Tranah and other aging and longevity experts at CPMCRI. Review a blog post that describes the documentary and includes a link to the trailer. 


 

Training

Dr. Tranah received his Ph.D. in ecology from the University of California, Davis, and completed postdoctoral work in epidemiology at the Harvard School of Public Health in Boston, Massachusetts.


 

Publication Search

Publications

Dong J, Pinto JM, Guo X, Alonso A, Tranah G, Cauley JA, Garcia M, Satterfield S, Huang X, Harris T, Mosley TH Jr, Chen H, The Prevalence of Anosmia and Associated Factors Among U.S. Black and White Older Adults. J Gerontol A Biol Sci Med Sci

Ben-Avraham D, Karasik D, Verghese J, Lunetta KL, Smith JA, Eicher JD, Vered R, Deelen J, Arnold AM, Buchman AS, Tanaka T, Faul JD, Nethander M, Fornage M, Adams HH, Matteini AM, Callisaya ML, Smith AV, Yu L, De Jager PL, Evans DA, Gudnason V, Hofman A, Pattie A, Corley J, Launer LJ, Knopman DS, Parimi N, Turner ST, Bandinelli S, Beekman M, Gutman D, Sharvit L, Mooijaart SP, Liewald DC, Houwing-Duistermaat JJ, Ohlsson C, Moed M, Verlinden VJ, Mellström D, van der Geest JN, Karlsson M, Hernandez D, McWhirter R, Liu Y, Thomson R, Tranah GJ, Uitterlinden AG, Weir DR, Zhao W, Starr JM, Johnson AD, Ikram MA, Bennett DA, Cummings SR, Deary IJ, Harris TB, Kardia SL, Mosley TH, Srikanth VK, Windham BG, Newman AB, Walston JD, Davies G, Evans DS, Slagboom EP, Ferrucci L, Kiel DP, Murabito JM, Atzmon G, The complex genetics of gait speed: genome-wide meta-analysis approach. Aging (Albany NY)

Evans DS, Avery CL, Nalls MA, Li G, Barnard J, Smith EN, Tanaka T, Butler AM, Buxbaum SG, Alonso A, Arking DE, Berenson GS, Bis JC, Buyske S, Carty CL, Chen W, Chung MK, Cummings SR, Deo R, Eaton CB, Fox ER, Heckbert SR, Heiss G, Hindorff LA, Hsueh WC, Isaacs A, Jamshidi Y, Kerr KF, Liu F, Liu Y, Lohman KK, Magnani JW, Maher JF, Mehra R, Meng YA, Musani SK, Newton-Cheh C, North KE, Psaty BM, Redline S, Rotter JI, Schnabel RB, Schork NJ, Shohet RV, Singleton AB, Smith JD, Soliman EZ, Srinivasan SR, Taylor HA Jr, Van Wagoner DR, Wilson JG, Young T, Zhang ZM, Zonderman AB, Evans MK, Ferrucci L, Murray SS, Tranah GJ, Whitsel EA, Reiner AP, CHARGE QRS Consortium., Sotoodehnia N, Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans. Hum Mol Genet

Willcox BJ, Morris BJ, Tranah GJ, Chen R, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Gerschenson M, Davy PMC, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Donlon TA, Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations. J Gerontol A Biol Sci Med Sci

Donlon TA, Morris BJ, He Q, Chen R, Masaki KH, Allsopp RC, Willcox DC, Tranah GJ, Parimi N, Evans DS, Flachsbart F, Nebel A, Kim DH, Park J, Willcox BJ, Association of Polymorphisms in Connective Tissue Growth Factor and Epidermal Growth Factor Receptor Genes With Human Longevity. J Gerontol A Biol Sci Med Sci

Matteini AM, Tanaka T, Karasik D, Atzmon G, Chou WC, Eicher JD, Johnson AD, Arnold AM, Callisaya ML, Davies G, Evans DS, Holtfreter B, Lohman K, Lunetta KL, Mangino M, Smith AV, Smith JA, Teumer A, Yu L, Arking DE, Buchman AS, Chibinik LB, De Jager PL, Evans DA, Faul JD, Garcia ME, Gillham-Nasenya I, Gudnason V, Hofman A, Hsu YH, Ittermann T, Lahousse L, Liewald DC, Liu Y, Lopez L, Rivadeneira F, Rotter JI, Siggeirsdottir K, Starr JM, Thomson R, Tranah GJ, Uitterlinden AG, Völker U, Völzke H, Weir DR, Yaffe K, Zhao W, Zhuang WV, Zmuda JM, Bennett DA, Cummings SR, Deary IJ, Ferrucci L, Harris TB, Kardia SL, Kocher T, Kritchevsky SB, Psaty BM, Seshadri S, Spector TD, Srikanth VK, Windham BG, Zillikens MC, Newman AB, Walston JD, Kiel DP, Murabito JM, GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell

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Gregory Tranah, Ph.D., Senior Scientist
Primary Research Interests
  • Epidemiology of aging and age-related diseases
  • Genetics of cognitive function, osteoporosis, osteoarthritis, and sleep
  • The role of mitochondrial DNA in human energetics and aging