Katie L. Stone, Ph.D., Senior Scientist

California Pacific CURRENTS: The online journal of CPMC Research Institute

Improving the understanding of sleep disorders in older adults
  • relationship of hypoxia, sleep fragmentation, and a measure of sleep duration on risk for mild cognitive impairment or dementia

    The study investigated the relationship of hypoxia, sleep fragmentation, and a measure of sleep duration on risk for mild cognitive impairment or dementia. Two measures of hypoxia (an oxygen desaturation index of ≥15 and a high percentage of total sleep time [>7%] in apnea or hypopnea) were associated with higher incidence of mild cognitive impairment or dementia (oxygen desaturation index: OR, 1.67 [95% CI, 1.03-2.69]; sleep time in apnea or hypopnea: OR, 1.79 [95% CI, 1.01-3.20]).

    Source:  Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, Ancoli-Israel S, Stone KL. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 2011;306(6):613-9. doi: 10.1001/jama.2011.1115. (Table 3) Copyright © (2011) American Medical Association. All rights reserved.

  • Association between sleep duration and 24-hour urine free cortisol in the MrOS Sleep Study

    Association of self-reported sleep duration and 24-hour urine free cortisol among those without depression and those without a history of CVD.

    24-hour urine free cortisol results are adjusted means (95% confidence intervals). Results for the not depressed sub-group adjusted for age, race, apnea-hypopnea index, BMI, history of CVD and physical activity. Results from those without a history of CVD adjusted for age, race, apnea-hypopnea index, BMI, physical activity, and number of depressive symptoms.

    Source:  Rao MN, Blackwell T, Redline S, Punjabi NM, Barrett-Connor E, Neylan TC, Stone KL; Osteoporotic Fractures in Men (MrOS) Study Group. Association between sleep duration and 24-hour urine free cortisol in the MrOS Sleep Study. PLoS One 2013;8(9):e75205. doi: 10.1371/journal.pone.0075205. (Figure 1)

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Research Overview

  • Dr. Stone conducts large-scale multi-center cohort studies exploring the relationships between sleep and age-related health outcomes including cognitive impairment and dementia, cardiovascular disease, and mortality.
  • In collaboration with Drs. Steve Cummings and Greg Tranah at the San Francisco Coordinating Center, Dr. Stone’s studies are being analyzed to determine genes linked to insomnia, sleep apnea, and other sleep disturbances. Results of these investigations may yield new targets for sleep disorder therapies.
  • Dr. Stone is planning randomized trials to evaluate the effectiveness of treatments for sleep disorders in older adults, and their impact on cognitive function, risk of falls, and other health-related outcomes.
  • A charter member of the National Institutes of Health: Cardiovascular and Sleep Epidemiology Study Section, Dr. Stone is Co-chair of the Clinical Trials Outcomes Working Group of the National Sleep Research Network. She serves on the advisory board of CPMC’s Brain Health Center.

Learn more about research in the Center for Research on Human Aging.


Training

Dr. Stone received her M.A. in biostatistics and her Ph.D. in epidemiology from the University of California, Berkeley.


 

Publication Search

Publications

Raman D, Kaffashi F, Lui LY, Sauer WH, Redline S, Stone P, Cawthon PM, Stone KL, Ensrud KE, Ancoli-Israel S, Loparo K, Mehra R, Polysomnographic Heart Rate Variability Indices and Atrial Ectopy Associated with Incident Atrial Fibrillation Risk in Older Community-dwelling Men. JACC Clin Electrophysiol

Spira AP, Stone KL, Redline S, Ensrud KE, Ancoli-Israel S, Cauley JA, Yaffe K, Actigraphic Sleep Duration and Fragmentation in Older Women: Associations With Performance Across Cognitive Domains. Sleep

Smagula SF, Harrison S, Cauley JA, Ancoli-Israel S, Cawthon PM, Cummings S, Stone KL, Determinants of Change in Objectively Assessed Sleep Duration Among Older Men. Am J Epidemiol

Blackwell T, Paudel M, Redline S, Ancoli-Israel S, Stone KL, Osteoporotic Fractures in Men (MrOS) Study Group., A novel approach using actigraphy to quantify the level of disruption of sleep by in-home polysomnography: the MrOS Sleep Study: Sleep disruption by polysomnography. Sleep Med

Furihata R, Hall MH, Stone KL, Ancoli-Israel S, Smagula SF, Cauley JA, Kaneita Y, Uchiyama M, Buysse DJ, Study of Osteoporotic Fractures (SOF) Research Group., An Aggregate Measure of Sleep Health Is Associated With Prevalent and Incident Clinically Significant Depression Symptoms Among Community-Dwelling Older Women. Sleep

Paudel ML, Taylor BC, Vo TN, Kats AM, Schousboe JT, Lui LY, McCulloch CE, Langsetmo L, Ancoli-Israel S, Redline S, Yaffe K, Stone KL, Hillier TA, Ensrud KE, Study of Osteoporotic Fractures., Sleep Disturbances and Risk of Hospitalization and Inpatient Days Among Older Women. Sleep

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Katie L. Stone, Ph.D., Senior Scientist
Primary Research Interests
  • Sleep and age-related health outcomes