Katie L. Stone, Ph.D., Senior Scientist

California Pacific CURRENTS: The online journal of CPMC Research Institute

Improving the understanding of sleep disorders in older adults
  • relationship of hypoxia, sleep fragmentation, and a measure of sleep duration on risk for mild cognitive impairment or dementia

    The study investigated the relationship of hypoxia, sleep fragmentation, and a measure of sleep duration on risk for mild cognitive impairment or dementia. Two measures of hypoxia (an oxygen desaturation index of ≥15 and a high percentage of total sleep time [>7%] in apnea or hypopnea) were associated with higher incidence of mild cognitive impairment or dementia (oxygen desaturation index: OR, 1.67 [95% CI, 1.03-2.69]; sleep time in apnea or hypopnea: OR, 1.79 [95% CI, 1.01-3.20]).

    Source:  Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, Ancoli-Israel S, Stone KL. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 2011;306(6):613-9. doi: 10.1001/jama.2011.1115. (Table 3) Copyright © (2011) American Medical Association. All rights reserved.

  • Association between sleep duration and 24-hour urine free cortisol in the MrOS Sleep Study

    Association of self-reported sleep duration and 24-hour urine free cortisol among those without depression and those without a history of CVD.

    24-hour urine free cortisol results are adjusted means (95% confidence intervals). Results for the not depressed sub-group adjusted for age, race, apnea-hypopnea index, BMI, history of CVD and physical activity. Results from those without a history of CVD adjusted for age, race, apnea-hypopnea index, BMI, physical activity, and number of depressive symptoms.

    Source:  Rao MN, Blackwell T, Redline S, Punjabi NM, Barrett-Connor E, Neylan TC, Stone KL; Osteoporotic Fractures in Men (MrOS) Study Group. Association between sleep duration and 24-hour urine free cortisol in the MrOS Sleep Study. PLoS One 2013;8(9):e75205. doi: 10.1371/journal.pone.0075205. (Figure 1)

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Research Overview

  • Dr. Stone conducts large-scale multi-center cohort studies exploring the relationships between sleep and age-related health outcomes including cognitive impairment and dementia, cardiovascular disease, and mortality.
  • In collaboration with Drs. Steve Cummings and Greg Tranah at the San Francisco Coordinating Center, Dr. Stone’s studies are being analyzed to determine genes linked to insomnia, sleep apnea, and other sleep disturbances. Results of these investigations may yield new targets for sleep disorder therapies.
  • Dr. Stone is planning randomized trials to evaluate the effectiveness of treatments for sleep disorders in older adults, and their impact on cognitive function, risk of falls, and other health-related outcomes.
  • A charter member of the National Institutes of Health: Cardiovascular and Sleep Epidemiology Study Section, Dr. Stone is Co-chair of the Clinical Trials Outcomes Working Group of the National Sleep Research Network. She serves on the advisory board of CPMC’s Brain Health Center.

Learn more about research in the Center for Research on Human Aging.


Training

Dr. Stone received her M.A. in biostatistics and her Ph.D. in epidemiology from the University of California, Berkeley.


 

Publication Search

Publications

Stone KL, Lui LY, Christen WG, Troen AM, Bauer DC, Kado D, Schambach C, Cummings SR, Manson JE, Effect of Combination Folic Acid, Vitamin B6 , and Vitamin B12 Supplementation on Fracture Risk in Women: A Randomized, Controlled Trial. J Bone Miner Res

Leng Y, Diem SJ, Stone KL, Yaffe K, Antidepressant Use and Cognitive Outcomes in Very Old Women. J Gerontol A Biol Sci Med Sci

Rogers TS, Harrison S, Swanson C, Cauley JA, Barrett-Connor E, Orwoll E, Stone KL, Lane NE, Osteoporotic Fractures in Men (MrOS) Study Research Group., Rest-activity circadian rhythms and bone mineral density in elderly men. Bone Rep

Chen H, Cade BE, Gleason KJ, Bjonnes AC, Stilp AM, Sofer T, Conomos MP, Ancoli-Israel S, Arens R, Azarbarzin A, Bell GI, Below JE, Chun S, Evans DS, Ewert R, Frazier-Wood AC, Gharib SA, Haba-Rubio J, Hagen EW, Heinzer R, Hillman DR, Johnson WC, Kutalik Z, Lane JM, Larkin EK, Lee SK, Liang J, Loredo JS, Mukherjee S, Palmer LJ, Papanicolaou GJ, Penzel T, Peppard PE, Post WS, Ramos AR, Rice K, Rotter JI, Sands SA, Shah NA, Shin C, Stone KL, Stubbe B, Sul JH, Tafti M, Taylor KD, Teumer A, Thornton TA, Tranah GJ, Wang C, Wang H, Warby SC, Wellman DA, Zee PC, Hanis CL, Laurie CC, Gottlieb DJ, Patel SR, Zhu X, Sunyaev SR, Saxena R, Lin X, Redline S, Multi-ethnic Meta-analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea Related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol

Song Y, Harrison SL, Martin JL, Alessi CA, Ancoli-Israel S, Stone KL, Fredman L, Changes in Caregiving Status and Intensity and Sleep Characteristics Among High and Low Stressed Older Women. J Clin Sleep Med

Raman D, Kaffashi F, Lui LY, Sauer WH, Redline S, Stone P, Cawthon PM, Stone KL, Ensrud KE, Ancoli-Israel S, Loparo K, Mehra R, Polysomnographic Heart Rate Variability Indices and Atrial Ectopy Associated with Incident Atrial Fibrillation Risk in Older Community-dwelling Men. JACC Clin Electrophysiol

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Katie L. Stone, Ph.D., Senior Scientist
Primary Research Interests
  • Sleep and age-related health outcomes