Peggy Cawthon, Ph.D., M.P.H., Senior Scientist

California Pacific CURRENTS: The online journal of CPMC Research Institute

Using large-cohort studies to understand age-related physical decline
  • Predicted probability of frailty status at follow-up

    Predicted probability of frailty status at follow-up, by quartile of bioavailable testosterone and frailty status at baseline for a 73.4-yr-old man. Cut-points for quartiles of bioavailable testosterone: Q1, _165.4 ng/dl; Q2, 165.4 to _201.5 ng/dl; Q3, 201.5 to _241.9 ng/dl; and Q4, _241.9 ng/dl. Probabilities derived from a partial proportional odds model, with age and bioavailable testosterone meeting the proportionality assumption, and frailty status at baseline not meeting the proportional odds assumption. The age assumed for the model (73.4 yr) is the mean age of the population at baseline.
    Source: Cawthon PM, et al, for the Osteoporotic Fractures in Men (MrOS) Research Group. J Clin Endocrinol Metab October 2009, 94(10):0000–0000. (Figure 3) First published ahead of print September 15, 2009 as doi:10.1210/jc.2009-0417

  • Adjusted survival plots for participants in the MrOS study

    Adjusted survival plots for participants in the MrOS study, by quartile of total intact PTH or 25(OH)D. Plots are adjusted for age, clinic, season of blood draw, serum calcium and phosphate, GFR, percentage body fat, weight, race, health status, presence of at least one medical condition, alcohol use, education, activity level (PASE score), marital status, and presence of a functional or mobility limitation.

    Source: Cawthon PM, et al, for the Osteoporotic Fractures in Men (MrOS) Research Group. Serum 25-Hydroxyvitamin D, Parathyroid Hormone, and Mortality in Older Men. J Clin Endocrinol Metab October 2010, 95(10):4625–4634. (Figure 1)

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Research Overview

  • Dr. Cawthon’s research on sarcopenia and age-related physical decline showed that tests of muscle strength and walking speed can help predict disability in older adults.
  • Using data from several ongoing large-cohort studies, she and colleagues at the San Francisco Coordinating Center (SFCC) study bone loss in older men; the association between vitamin D and mortality; risk factors for osteoporotic fractures in older women and men; and predictors of frailty in the elderly.
  • As part of her role at the SFCC, Dr. Cawthon co-leads multi-center observational studies, including the Study of Osteoporosis in Men (MrOS) and the Study of Osteoporotic Fractures (SOF) in women, and has analyzed data from the Health, Aging and Body Composition (Health ABC) and Framingham studies.

Learn more about research in the Center for Research on Human Aging.

A new documentary features Dr. Cawthon and other aging and longevity experts at CPMCRI. Review a blog post that describes the documentary and includes a link to the trailer. 


Training


Dr. Cawthon received her Ph.D. and M.P.H. from the University of California, Berkeley.


 

Publication Search

Publications

Shepherd JA, Ng BK, Fan B, Schwartz AV, Cawthon P, Cummings SR, Kritchevsky S, Nevitt M, Santanasto A, Cootes TF, Modeling the shape and composition of the human body using dual energy X-ray absorptiometry images. PLoS One

Cawthon PM, Lui LY, Taylor BC, McCulloch CE, Cauley JA, Lapidus J, Orwoll E, Ensrud KE, Clinical Definitions of Sarcopenia and Risk of Hospitalization in Community-Dwelling Older Men: The Osteoporotic Fractures in Men Study. J Gerontol A Biol Sci Med Sci

Nielson CM, Wiedrick J, Shen J, Jacobs J, Baker ES, Baraff A, Piehowski P, Lee CG, Baratt A, Petyuk V, McWeeney S, Lim JY, Bauer DC, Lane NE, Cawthon PM, Smith RD, Lapidus J, Orwoll ES, Osteoporotic Fractures in Men (MrOS) Study Research Group., Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics. J Bone Miner Res

Schousboe JT, Vo TN, Langsetmo L, Taylor BC, Cawthon PM, Schwartz AV, Bauer DC, Orwoll ES, Lane NE, Barrett-Connor E, Ensrud KE, Osteoporotic Fractures in Men (MrOS) Study Research Group., Association of Trabecular Bone Score (TBS) With Incident Clinical and Radiographic Vertebral Fractures Adjusted for Lumbar Spine BMD in Older Men: A Prospective Cohort Study. J Bone Miner Res

Vandenput L, Mellström D, Laughlin GA, Cawthon PM, Cauley JA, Hoffman AR, Karlsson MK, Rosengren BE, Ljunggren Ö, Nethander M, Eriksson AL, Lorentzon M, Leung J, Kwok T, Orwoll ES, Ohlsson C, Low Testosterone, but Not Estradiol, Is Associated With Incident Falls in Older Men: The International MrOS Study. J Bone Miner Res

Murphy RA, Moore SC, Playdon M, Meirelles O, Newman AB, Milijkovic I, Kritchevsky SB, Schwartz A, Goodpaster BH, Sampson J, Cawthon P, Simonsick EM, Gerszten RE, Clish CB, Harris TB, Health ABC Study., Metabolites Associated With Lean Mass and Adiposity in Older Black Men. J Gerontol A Biol Sci Med Sci

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Peggy Cawthon, Ph.D., M.P.H., Senior Scientist
Primary Research Interests
  • Sarcopenia and age-related physical decline
  • The association between vitamin D and mortality
  • Risk factors for osteoporotic fractures in older women and men