- Dr. Soroceanu’s earlier research in collaboration with Dr. Charles Cobbs was aimed at determining the role of human cytomegalovirus (CMV) in tumorigenesis and understanding its oncomodulatory effects. Ongoing investigations in the Soroceanu lab will further explore CMV and its actions in promoting the immunosuppressive environment of brain tumors, and determine the effects of antiviral therapies as anti-tumor agents for glioblastoma.
- Working with fellow CPMCRI researchers Drs. Pierre Desprez and Sean McAllister, Dr. Soroceanu is studying the inhibition and down-regulation of the protein Id-1 in brain tumor cells by cannabinoid compounds including cannabidiol (CBD). She is also determining the efficacy of CBD and related compounds in sensitizing tumors to frontline therapeutics (e.g., chemotherapy).
- With researchers in the Kashani lab at CPMCRI, Dr. Soroceanu is investigating the mechanisms by which PHIP enhances the aggressiveness of cancer and determining whether inhibiting the protein will alter the aggressive behaviors of gliomas in vivo.
Dr. Soroceanu received her M.D. from the School of Medicine at the University of Iasi, Romania, and her Ph.D. in neurobiology from the University of Alabama. Before joining CPMCRI in 2006, she completed post-doctoral work in neuro-oncology at Genentech.
McAllister SD, Soroceanu L, Desprez PY, The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids. J Neuroimmune Pharmacol
Dar AA, Nosrati M, Bezrookove V, de Semir D, Majid S, Thummala S, Sun V, Tong S, Leong SP, Minor D, Billings PR, Soroceanu L, Debs R, Miller JR 3rd, Sagebiel RW, Kashani-Sabet M, The role of BPTF in melanoma progression and in response to BRAF-targeted therapy. J Natl Cancer Inst
Fiallos E, Judkins J, Matlaf L, Prichard M, Dittmer D, Cobbs C, Soroceanu L, Human cytomegalovirus gene expression in long-term infected glioma stem cells. PLoS One
Cobbs C, Khan S, Matlaf L, McAllister S, Zider A, Yount G, Rahlin K, Harkins L, Bezrookove V, Singer E, Soroceanu L, HCMV glycoprotein B is expressed in primary glioblastomas and enhances growth and invasiveness via PDGFR-alpha activation. Oncotarget
Hadaczek P, Ozawa T, Soroceanu L, Yoshida Y, Matlaf L, Singer E, Fiallos E, James CD, Cobbs CS, Cidofovir: a novel antitumor agent for glioblastoma. Clin Cancer Res
Matlaf LA, Harkins LE, Bezrookove V, Cobbs CS, Soroceanu L, Cytomegalovirus pp71 protein is expressed in human glioblastoma and promotes pro-angiogenic signaling by activation of stem cell factor. PLoS One