Biomarker Discovery

California Pacific CURRENTS: The online journal of CPMC Research Institute

heat map

Microarray technology is a powerful tool in the discovery of new biomarkers for diseases. Shown here is a heat map illustrating the expression patterns of genes (in peripheral blood) implicated in the immune response after kidney transplant.


Overview

Researchers at CPMCRI are using genome-wide approaches to identify cancer progression genes. Ongoing work is aimed at investigating and validating the role of several of these genes (including microRNAs) as molecular markers underlying the development and progression of cancer, using melanoma as a model. Taking biomarkers from initial discovery to clinical application, our investigators have uncovered novel biomarkers associated with distinct stages of melanoma progression.


Investigators and research areas

 

Kidney/solid organ transplant rejection and tolerance

 

Molecular prognostic and predictive factors in melanoma